ABSTRACT
Background: Nutrient foramen is an opening over which the nutrient artery enters and supplies the shaft of thelong bones. The nutrient foramen usually lies near the soleal line and transmits a branch of the posterior tibialartery. The posterior tibial artery is a branch from the popliteal artery. The nutrient vessel may also arise at thelevel of the popliteal bifurcation or as a branch from the anterior tibial artery.Methods: The present study was conducted on 200 dry human tibia bones of unknown sex and age. The tibiabones were observed for nutrient foramen macroscopically.Results: In our study the right sided 7 tibia bones and 6 left sided tibia bones have double nutrient foramen. Theposition of the nutrient foramen in the upper 1/3rd is observed in 77.47% tibia and in the middle 1/3rd in 17.84%of the tibia.The direction of the nutrient foramen is downwards in all the tibia bonesConclusions: The tibia is the most commonly fractured long bone and contributes significantly to the fracturecare worldwide. Fracture of the tibia through the nutrient canal disrupts the blood flow in the nutrient artery,thus contributing delayed union and non-union of the bone. Knowledge of the blood supply and location ofnutrient foramen is important in the treatment and planning of surgery in fractures.
ABSTRACT
ABSTRACT The actinobacterial strain Streptomyces lavendulocolor VHB-9 was isolated from granite mine soil samples of Khammam district, Telangana state, India. The strain was identified based on detailed microorphological, cultural and phylogenetic analysis. Bioactive guided isolation of the secondary metabolites of the strain was carried out by growing the strain in optimized medium (0.5% lactose, 0.5% peptone, 0.05% K2HPO4, 0.2% CaCO3 with pH adjusted to 7.0). Separation and purification of the active fractions from the crude ethyl acetate extract was carried out by silica gel column chromatography and resulted in the isolation of two active fractions. Structural elucidation of the two (B2 and B3) active compounds was carried out by FT-IR, Mass and NMR spectroscopy and were identified as Bis (7-methyloctyl) phthalate and (Z)-3-aminoacrylic acid. The antimicrobial activity of the bioactive compounds produced by S. lavendulocolor VHB-9 was expressed in terms of minimum inhibitory concentration against opportunistic pathogenic bacteria and fungi. Both fractions exhibited good antimicrobial potential against the bacteria and fungi tested.